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Schlosstein, L. High association of an HL-A antigen, W27, with ankylosing spondylitis. Cortes, A. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Genomes Project, C.

Ankylosing Spondylitis

A map of human genome variation from population-scale sequencing. Nature , — McCarthy, M. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Tennessen, J. Evolution and functional impact of rare coding variation from deep sequencing of human exomes.


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Science , 64—69 Fu, W. Analysis of 6, exomes reveals the recent origin of most human protein-coding variants. Kryukov, G. Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. Franke, A. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Barrett, J. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Wolf, N. Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease.

Anderson, C. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.


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  6. Gastroenterology , —, e3 Zeggini, E. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

    Pentoxifylline as a new adjunctive therapy in ankylosing spondylitis: A randomized clinical trial

    Science , — Kwan, T. Tissue effect on genetic control of transcript isoform variation. Di Meglio, P. Sarin, R. Natl Acad. USA , — Morgan, A. Abad, C. Genes Immun. De Keyser, F. Bowel inflammation and the spondyloarthropathies. North Am. De Vos, M. Ileocolonoscopy in seronegative spondylarthropathy. Gastroenterology 96 , — Mielants, H. HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis. Thjodleifsson, B. A common genetic background for inflammatory bowel disease and ankylosing spondylitis: a genealogic study in Iceland.

    Arthritis Rheumatol.

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    Frisell, T. Parkes, M. Genetic insights into common pathways and complex relationships among immune-mediated diseases. The genetics of ankylosing spondylitis and axial spondyloarthritis. Boucquey, M. Noxp20 and Noxp70, two new markers of early neuronal differentiation, detected in teratocarcinoma-derived neuroectodermic precursor cells. Lee, S. Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection.

    Natl Acad Sci. Kenna, T. Immunopathogenesis of ankylosing spondylitis.

    Complete Medical Guide for Disease Volume V: Ankylosing Spondylitis

    Adzhubei, I. A method and server for predicting damaging missense mutations. Methods 7 , — Grall, A. PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Yang, J. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.

    Costello, M. Intestinal dysbiosis in ankylosing spondylitis. Microbes, the Gut and Ankylosing Spondylitis.

    Pentoxifylline as a new adjunctive therapy in ankylosing spondylitis: A randomized clinical trial

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