Writing Workshop: Self-Publishing Formatting. In my last post, I mentioned that I teach Writing Workshops. Well, this week is all about self-publishing so I thought I'd share one of the documents I created for it. Future Plans. I've not been blogging for a while. I've also not been writing as much. I've always written while having a job and often while attending college.
But I wasn't really prepared for the exhaustion from chronic illness coupled with a promotion at my job. Most days, I come home and crawl into bed under the covers. My mind is always going, but sitting down at the keys and actually "working" eludes me. For the past year, I've been hosting "Writing W. Last year didn't exactly go as planned for releases. That's why this year, I'm airing on the side of conservative.
This will be a J. As for which one it will be, I'm not sure. I've been working on this story for a long time - it was originally. Edits and Upcoming Releases. Camp NaNo began on Wednesday. I set a moderate goal for 25, words after crashing and burning back in April. So far as of this post, at least I'm on track to finish. While I'm jumping headlong into a sequel, I'm knee-deep in edits for Blood Ties 1. The Blood Ties series will likely be at least four 15, or so word novellas - maybe longer.
I'm hoping to release the first two in fairly quick succes.
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Let's face it - I'm not the most active blogger. I could say that a resolution for would involve more blog posts. But I won't. Well, the best reason would be for me to write more novels. The other reason would be that I forget to blog and then bam, it's been six months. Fret not, dear readers. I will still occasionally blog - in the erratic style to which I'm sure you've all become accustom to. Now, the topic of today's p. Reviews and Readers. I love to connect with and hear from my readers. It's one of the great joys and privileges of being a writer. It's also a great responsibility.
I do read reviews of my work. It's an avenue of contact and I love feedback. I like to know what parts you, the readers, enjoyed and loved, the characters that you care about, and also what you didn't like. I went back and rearranged scenes as. Upcoming Releases! Happy Holidays, readers! As comes to a close, I'm excited to give out little teasers about what's coming up next! All dates are subject to change and details might vary, but this a preview of what's ahead! That date might be sooner or later depending on the editing and uploading process.
Mini-Blogs: Catch-up! Here's the latest! The print edition is being formatted and should release later this month original release was scheduled for September, but c. Long time, no blog! So here's a few mini-blogs Typos, typos, typos everywhere! I'd just relocated the day before release and was still unpacking. By the time I got around to looking at the finished product on my Nook, it was January. From the tiny excerpt at the opening to the back cover copy, I located several easy errors. So easy that if I were reading the sample or. Very often, this idea comes in the form of a question - WWAD?
In simple terms: What Would Aidan Do? WWAD if his wife disappeared and a body surface in the place where she was last seen? WWAD if all the evidence points. Behind the Screen. Part of my reason for starting this blog was to talk about my inspirations behind the stories. Based loosely on a fan fiction I wrote back in The first half of the story bares little resemblance to the fan fiction and the characters have new names and backgrounds. It's November, which is one of my favorite times of the year. Why, you ask? Because, it's NaNo time, baby!
The goal of NaNo is to write a novel in any genre in 30 days. What counts as a novel? For NaNo, 50, words is considered "winning". Most BRCA1 pathogenic variants lead to frameshifts resulting in a missing or non-functional protein. In cancers from individuals with a BRCA1 germline pathogenic variant , the normal allele is deleted or inactivated, resulting in somatic inactivation of BRCA1. This strongly suggests that BRCA1 is a tumor-suppressor gene whose loss of function can result in genomic instability, resulting in a high susceptibility to malignant transformation [ Smith et al , Deng ].
Additional evidence in support of a tumor suppressor function is that overexpression of the BRCA1 protein leads to growth suppression similar to that seen with the classic tumor suppressors TP53 and the retinoblastoma gene RB1 [ Holt et al ]. BRCA2 encodes a Overall, approximately 2. In the future, some of these will likely prove to be benign variants without clinical significance, while others may be associated with an increased cancer risk. There is evidence that p.
LysTer is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2 , although penetrance is reduced. This was demonstrated through a large case-control study based on an international consortium of patients with cancer. Further studies are needed to determine the biologic mechanism of action responsible for these associations [ Meeks et al ].
BRCA2 encodes a kd protein of 3, amino acids. BRCA2 is a phosphoprotein normally located in the nucleus [ Bertwistle et al ]. BRCA2 protein has no recognizable protein motifs and no apparent relation to the breast cancer type 1 susceptibility protein. Like BRCA1 , BRCA2 is expressed in most tissues and cell types analyzed, indicating that gene expression does not account for the tissue-restricted phenotype of breast and ovarian cancer.
BRCA2 transcription is induced late in the G 1 phase of the cell cycle and remains elevated during the S phase, indicating some role in DNA synthesis [ Rajan et al , Vaughn et al ]. The breast cancer type 2 susceptibility protein interacts with the RAD51 protein, a key component in homologous recombination and double-strand break repair [ Sharan et al , Wong et al ]. Complete loss of Brca2 in the mouse is embryonic lethal, characterized by a lack of cell proliferation [ Ludwig et al , Sharan et al , Suzuki et al ]. Therefore, the available evidence indicates that BRCA2 is a "caretaker," like TP53 , serving to maintain genomic integrity [ Zhang et al ].
It is likely that BRCA2 will eventually be implicated in a variety of cellular processes, only some of which will be related to their role in the etiology of breast and ovarian cancer. Most BRCA2 pathogenic variants reported to date consist of frameshift deletions, insertions, or nonsense variants that predict premature truncation of protein transcription, consistent with the loss of function that is expected with clinically significant variants of tumor suppressor genes.
Cells lacking BRCA2 are deficient in the repair of double-strand DNA breaks, as reflected in a hypersensitivity to ionizing radiation [ Venkitaraman ]. No further modifications are allowed. For clarity, excerpts of GeneReviews chapters for use in lab reports and clinic notes are a permitted use. For questions regarding permissions or whether a specified use is allowed, contact: ude. Turn recording back on. National Center for Biotechnology Information , U.
GeneReviews by Title. Search term. GeneReviews Advanced Search Help. Summary Clinical characteristics. Genetic counseling. Breast cancer diagnosed at any age in an individual of Ashkenazi Jewish ancestry. In most cases, relatives at risk need only be tested for the family-specific germline pathogenic variant, except in the following situations:.
Individuals of Ashkenazi Jewish heritage should consider testing for all three founder germline pathogenic variants because of the high population frequency of these founder pathogenic variants as well as reports of the coexistence of more than one founder germline pathogenic variant in some families. Note: 1 The genes included in the panel and the diagnostic sensitivity of the testing used for each gene vary by laboratory and over time. For an introduction to multigene panels click here.
More detailed information for clinicians ordering genetic tests can be found here. Table 1.
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Clinical Characteristics Clinical Description BRCA1- and BRCA2- associated hereditary breast and ovarian cancer syndrome HBOC is characterized by an increased risk for male and female breast cancer, ovarian cancer includes fallopian tube and primary peritoneal cancers , and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a BRCA2 pathogenic variant.
Table 2. Phenotype Correlations by Gene Ovarian cancer and primary papillary serous carcinoma of the peritoneum are considerably more common and tend to develop at an earlier age in women with a germline BRCA1 pathogenic variant as compared to women with a germline BRCA2 pathogenic variant [ Casey et al , Yates et al ]. The combined frequency of the following three pathogenic variants in the Ashkenazi Jewish population is [ King et al ]: BRCA1 c. BRCA1 c. Differential Diagnosis Syndromic breast cancer. Table 3. Survivors are at increased risk for multiple primary cancers.
Ruijs et al . Prevention of Primary Manifestations Breast cancer Consider prophylactic bilateral mastectomy. Given the conflicting data on the degree of risk reduction of breast cancer associated with prophylactic oophorectomy, consider discussing the risks and benefits of this approach with a genetics specialist.
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The sample size, however, was extremely small. Consider prophylactic oophorectomy, recognizing that completion of childbearing may factor into this decision. Recent advances in understanding the molecular events preceding ovarian cancer have established the fallopian tube as the origin of the majority of high-grade serous ovarian cancers, leading to the consideration of salpingectomy with ovarian retention until the age of natural menopause as the first step in primary prevention. This approach is likely to reduce the health hazards of premature menopause, but its adoption will require prospective data to establish its safety and efficacy [ Daly et al ].
Tubal ligation. Note: There is no evidence that use of current after oral contraceptive formulations increases the risk for early-onset breast cancer for women with a germline BRCA1 or BRCA2 pathogenic variant.
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Prevention of Secondary Complications Significant adverse consequences of tamoxifen treatment included higher rates of endometrial cancer and thromboembolic episodes including pulmonary embolism in those individuals who took the medication than in those who did not. Surveillance Women Monthly breast self-examination. Annual breast MRI beginning at age 25, or individualized based on family history if a breast cancer diagnosis before age 30 is present. Annual transvaginal ultrasound and serum CA concentration beginning at age 35 years or individualized based on the earliest age of onset in the family may be considered for those women who have not elected to undergo prophylactic oophorectomy.
Breast self-examination training and regular monthly breast self-examination beginning at age Screening of asymptomatic individuals for pancreatic cancer is not generally recommended, but is possible in research settings. Evaluation of Relatives at Risk Once a cancer-predisposing BRCA1 or BRCA2 germline variant has been identified in a family, testing of at-risk relatives can identify those family members who also have the familial variant and thus need increased surveillance and early intervention when a cancer is identified.
Therapies Under Investigation Several studies currently underway are looking at novel approaches to the treatment of BRCA -associated breast and ovarian cancer. Other Hormone replacement therapy HRT. Genetic Counseling Genetic counseling is the process of providing individuals and families with information on the nature, inheritance, and implications of genetic disorders to help them make informed medical and personal decisions. The parent with the variant may or may not have had a cancer diagnosis depending on the following variables:.
It is appropriate to offer molecular genetic testing to both parents of an individual with a BRCA1 or BRCA2 germline pathogenic variant to determine which side of the family is at risk. Generally, the pattern of cancers seen in the family usually guides which parent is tested first. Related Genetic Counseling Issues See Management, Evaluation of Relatives at Risk for information on evaluating at-risk relatives for the purpose of early diagnosis and treatment.
Family planning The optimal time for the determination of genetic risk and discussion of the availability of prenatal testing is before pregnancy. It is appropriate to offer genetic counseling including discussion of potential risks to offspring and reproductive options to young adults who are affected or at risk. Breast Cancer Information Core. A discussion forum specifically for women who are at a high risk of developing ovarian cancer or breast cancer.
Hereditary Breast and Ovarian Cancer. An advocacy group seeking public policy change to benefit breast cancer patients and survivors. Breast Cancer. Breast and ovarian cancer. Probability of Breast Cancer in American Women. Information, referrals to treatment centers. Answers questions from recently diagnosed women and provides emotional support. Funds research programs for women who do not have adequate medical service and support. PROMPT is an online research registry for patients and families who have undergone multiplex genetic testing and were found to have a genetic variation which may be linked to an increased risk of having cancer.
Table A. Table B. Table 4. ArgGln c. Variant designation that does not conform to current naming conventions.
Two nuclear localization signals located in exon Table 5. SerArgfsTer22 c. American Society of Clinical Oncology. Policy statement update: genetic testing for cancer susceptibility. Available online. Accessed Ethical and policy issues in genetic testing and screening of children.
National Society of Genetic Counselors. Position statement on genetic testing of minors for adult-onset conditions. Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Cancer Inst. J Clin Oncol.
Anglian Breast Cancer Study Group. Br J Cancer. Breast-cancer risk in families with mutations in PALB2. N Engl J Med. A prospective study. Gynecol Oncol. Cancer Epidemiol Biomarkers Prev. Nuclear location and cell cycle regulation of the BRCA2 protein. Cancer Res. Biggs PJ, Bradley A.
A step toward genotype-based therapeutic regimens for breast cancer in patients with BRCA2 mutations? Trends Biochem Sci. Prognosis of BRCA-associated breast cancer: a summary of evidence. Breast Cancer Res Treat. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. BRCA1-associated tumorigenesis: what have we learned from knockout mice?
Trends Genet. Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. J Med Genet. Brugarolas J, Jacks T. Double indemnity: p53, BRCA and cancer. Nat Med. High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome. Callebaut I, Mornon JP. FEBS Lett. Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations.
Am J Hum Genet. Mol Cell. BRCA1 is a kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. Hum Reprod Update. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet. Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage: implications for sister chromatid cohesion, genome stability, and carcinogenesis. Salpingectomy as a means to reduce ovarian cancer risk. Cancer Prev Res Phila. Deng CX. Nucleic Acids Research. Tumor formation in Brca1 conditional mutant mice. Environ Mol Mutagen.
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The first day at his new office, in walks the sheriff, a stunner brunette in designer khakis. She begs Mackenzie to take a temporary assignment teaching at an inner-city school to help locate a drug lord. A tough task, Mack would be a bull in a china shop…. A breath of fresh air to have such intelligent and articulate vocabulary. Set in modern-day Australia and Cagliari, Sardinia.
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And by the way, they go well with chocolates. The next four mysteries only get more enticing! Can Mira James manage make-out time with guitar-slinging Johnny Leeson while winning a blue ribbon for caging a killer? You bet your last deep-fried Nut Goodie! So why would a team of killers want to murder him and frame it as a suicide? Lottie Lemon has a bakery to tend to, one too many suitors, and the supernatural ability to see the dead — which is always a warning of ominous things to come. Living in Honey Hollow can be murder. Lizzy turns to her alien-chasing friend, Peace Jones, and a Scottish battlefield ghost to find the killer.
Now, all she wants is for her life to return to normal. This tale of a small town sheriff is a breezy and entertaining read, with a compelling lead character. Gritty PI Vincent Malone offers to help. From there everything goes downhill. Archaeology, Indian artifacts, and crimes from the past weave into a mysterious plot involving political corruption, a wayward priest, millions in stolen relics, forgotten curses, and old misdeeds. The brothers have gotten into a good rhythm at their pub and makeshift office, and two job offers have come in.
But then comes the sort of case Joey loves… the difficult kind. But his troubles suddenly get a whole lot worse when he returns home one night to find his roommate murdered. A series of clues and desperate men in pursuit leads Peter to question his whole existence, and life will never be the same again! Instead of writing about the weekend bake sale, she has to give a statement to the police.